Abstract Background High-mobility group box 1 (HMGB1) is increased in breast cancer cells as the result of exposure to the secreted substances from cancer-associated fibroblasts and plays a crucial role in cancer progression and drug resistance.Its effect, however, on the expression of programmed death ligand 1 (PD-L1) in breast cancer cells has no
Nanosized drug delivery systems typically enter the Beauty Service/Accessories cell via endocytosis.However, a significant amount of the endocytosed cargo cannot effectively escape from the endosome, resulting in drug degradation.Therefore, there are several ongoing efforts to develop transmembrane delivery systems that could circumvent endocytosis
According to the geological condition and measured geostress data of the utralong-distance water diversion project,a 3D inversion calculation model of the initial geostress field of the water diversion route was established.The initial geostress field of the water diversion route was exactly simulated through the method of generalized regression ne
The efficiency of project implementation time becomes one of the efforts in optimizing the use of implementation time.CPM is one of the network methods used to determine the critical path of each implementation.This research aims to optimize Time by applying CPM methods in the Kadiri University Clinic construction project in Kediri.The project cons
Thrombotic thrombocytopenic purpura (TTP) is a life-threatening medical emergency which may be difficult to recognize given the wide spectrum in which it presents.A delay in treatment may be catastrophic as untreated cases of TTP have a mortality rate exceeding 90%.Given the high fatality rate of untreated TTP and its range of presenting symptoms,